Etwas Nettes als Einleitung
Jemand musste Josef K. verleumdet haben, denn ohne dass er etwas Böses getan hätte, wurde er eines Morgens verhaftet. »Wie ein Hund!« sagte er, es war, als sollte die Scham ihn überleben. Als Gregor Samsa eines Morgens aus unruhigen Träumen erwachte.
Anchor Karyotyping and Anchor Fluorescence Imaging und vielleicht noch Ikaros 7--> Sollen das Buttons sein?
Karyogram Creation
You may benefit most from the following customizations:
Prof. Dr. Claudia HaferlachOur lab had the opportunity to be the first user to test the betaversion of MetaSystems’ new AI-based karyotyping software Ikaros. We experienced a time gain of up to 50% in the karyotype analysis of bone marrow metaphases. This enormous gain in efficiency allows us to keep pace with the ever-increasing workload in times of shortage of personnel resources.
MD from MLL
(Münchner Leukämielabor GmbH, Germany)
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The Ikaros software integrates an intuitive graphical user interface with a range of potent processing tools, delivering the necessary flexibility in the process of karyogram creation. Engineered to reduce the number of interactions, Ikaros holds the potential to decrease the time needed for both analysis and result review compared to a manual workflow.
Ikaros offers tools to assist cytogeneticists in evaluating metaphases prepared using various prevalent chromosome banding methods (such as G-Banding and Q-Banding). It also supports diverse specimen types, including peripheral blood, bone marrow, amniotic fluid, and chorionic villi.
Ikaros 7
The latest versions of Ikaros by MetaSystems have integrated features based on Deep Neural Networks (DNNs), designed to assist cytogeneticists in segmenting metaphase chromosomes and classifying them within the karyogram. This cutting-edge technology supersedes the respective algorithms used in earlier versions of Ikaros, offering the potential to markedly decrease the number of interactions needed in comparison to the former workflow.
Like its predecessors, the latest versions of Ikaros support users in separating chromosomes in the metaphase. However, the adoption of a DNN-based workflow marks a notable progression in this process, aiming to lower the rate of segmentation errors and consequently lessen the need for manual corrections by the users.
This introduces the deployment of the new DNN-based tools as an additional means to achieve time savings in metaphase processing.
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Fluorescence Imaging
You may benefit most from the following customizations:
- Effortlessly capture images with a single click, utilizing up to 12 color channels.
- Get correct exposures at the first shot, thanks to automatic integration time.
- Eliminate the need for time-consuming processing in a dark room.
- Utilize a monochrome camera for the independent acquisition of single-color channels, automatically merging them to create a color image.
- Refine and edit specific color channels or even individual areas within the image with selective editing capabilities.
- View individual color separations and explore various pseudo-color visualizations.
- Maintain a continuous log of processing steps and enjoy unrestricted access to the original images.
- Opt for optional upgrades to enable support for color karyotyping, Multicolor FISH (mFISH) and the exclusive Multicolor Chromosome Banding (mBAND) method.
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Moreover, Ikaros introduces a color fluorescence mode, displacing traditional photography and eliminating the time-consuming and laborious processing steps typically performed in a darkroom. Color images are produced by sequentially capturing monochrome images of the distinct color components and then automatically combining them to form a cohesive color image. The automated integration time control guarantees accurate exposures from the initial shot, eliminating the need for cumbersome test exposures or guesswork in determining the correct integration time. This not only reduces hands-on time but also extends the lifespan of the specimen. Even faint fluorescent signals against a strong counterstain result in clear and sharp images.
Frequently Asked Questions
No. In the new Ikaros, the DNN capabilities facilitate the segregation of chromosomes and their categorization into the appropriate karyogram classes. This process yields a preliminary suggestion that requires further assessment and potential modification by a skilled user. Ultimately, the cytogeneticist is responsible for creating the final karyogram and conducting its analysis.
Yes, once Ikaros generates a karyogram proposal via its DNN features, users have the possibility and the responsibility to review and, if needed, amend this proposal. They have access to the same respective tools that have been present in earlier versions of Ikaros. Nevertheless, when an appropriate DNN is utilized, it is anticipated that the need for manual adjustments will be considerably reduced compared to the machine learning algorithms used in prior versions.
The response to this inquiry is contingent on various elements. Factors such as the nature of preparations, working methods employed, and the time allocated for result verification and reporting all play crucial roles in determining processing time. Nonetheless, insights from laboratories that have adopted the new feature indicate a noticeable decrease in case processing times, attributed to the diminished requirement for manual intervention in contrast to the algorithms previously in use.
No, there is no need for a replacement. Starting with version 6.3, every new version of Ikaros comes ready for DNN-based chromosome separation and classification and can be upgraded to include this feature. For efficient handling of DNN operations, an additional graphics card is needed to facilitate the computations. This card can be installed directly in the workstation or in a distinct system. For further information on the technical options available, please feel free to get in touch with us.
Chromosome analysis with the help of karyograms is central to cytogenetics, and Ikaros enhances this process, allowing the users to set up a versatile digital workflow. The software supports various banding techniques, specimen types, and advanced image processing tools, all within an intuitive, customizable interface.
The latest versions of Ikaros offer the option of implementing Deep Neural Networks (DNN) in user workflows, which help reduce segmentation errors, minimize manual corrections, and save time in metaphase processing. The DNN technology optimizes chromosome segmentation and classification and provides an initial karyogram draft as a basis for expert review. Delivering these innovative features while maintaining backward compatibility, Ikaros ensures that long-time users can seamlessly transition to the latest version and decide how much of this functionality they want to implement in their workflows.
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Legal Note
Ikaros 6.3 (SaMD + System)
Ikaros 6.3 is classified as an in vitro diagnostic (IVD) medical device in the European Union in accordance with the In Vitro Diagnostic Medical Device Directive 98/79/EC. It carries the CE label unless otherwise indicated and must be used within the scope of its intended purpose.
Ikaros is utilized in numerous countries worldwide. However, its use for clinical diagnostics depends on the regulatory requirements of each respective country or region.
Some hardware components supplied by third-party manufacturers are not included in the Ikaros IVD product and are therefore not part of the IVD medical device.