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Ikaros software is trusted by over 2,000 users worldwide for karyogram generation and fluorescence imaging, establishing it as one of the most widely used image analysis solutions in clinical cytogenetics. Its success stems from a sophisticated, user-friendly interface and optimization for routine workflows. In addition, Ikaros provides a comprehensive set of tools designed to simplify and accelerate image processing.
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The latest and most advanced version of the software is Ikaros 7 which has been completely updated and improved. Almost every part of the software has been enhanced—while keeping the familiar structure users know. Most of the features are now easier to use, more intuitive, and faster to access.
The biggest innovation in Ikaros 7 is the seamless integration of artificial intelligence with Deep Neural Networks (DNN). Karyogram creation is now much faster, and the results can be safely reviewed and confirmed by the user in a transparent workflow. Ikaros 7 creates a karyogram draft directly from the original metaphase image and clearly labels it as a proposal. The cytogenetics expert can use all available tools in Ikaros to review and adjust the proposed karyogram. It's only added to the final list once the user confirms it with a single click.
The automatic creation of karyogram suggestions works with both manually captured images and images from a connected slide scanning system running the Metafer software. In all cases, the user's work in Ikaros begins with reviewing the karyogram proposal, while the time consuming image preparation is no longer needed.
My former laboratory at Hannover Medical School supported MetaSystems in adapting the AI functionality to the segmentation and classification of fluorescent R-banding (Vajen et al, PMID 34839233). With the help of the adapted AI, we were able to save more than 40% processing time with the karyotyping software Ikaros. As the new head of amedes genetics, I am pleased to see that the cytogenetic laboratory is equipped with solutions by MetaSystems for metaphase finding, karyotyping and FISH as well.
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Ikaros features a color fluorescence mode that replaces traditional photography, eliminating the need for time-consuming darkroom processing. It generates color images by sequentially capturing monochrome images of different color components and automatically merging them into a cohesive final image. With automated integration time control, it ensures precise exposures from the first shot, removing the need for test exposures or guesswork. This streamlines workflow, minimizes hands-on time, and helps preserve the specimen. Even weak fluorescent signals against a strong counterstain produce sharp and clear images.
Ikaros 6.3 is classified as an in vitro diagnostic (IVD) medical device in the European Union in accordance with the In Vitro Diagnostic Medical Device Directive 98/79/EC. It carries the CE label unless otherwise indicated and must be used within the scope of its intended purpose.
Ikaros is utilized in numerous countries worldwide. However, its use for clinical diagnostics depends on the regulatory requirements of each respective country or region.
Some hardware components supplied by third-party manufacturers are not included in the Ikaros IVD product and are therefore not part of the IVD medical device.